pentobarbital will lower the extent or impact of imatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.
pentobarbital will lower the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/ten metabolism. Insignificant/Significance Unknown.
With therapeutic doses of TCAs, barbiturates enhance metabolism and decrease blood concentrations of TCAs.
pentobarbital will reduce the extent or result of bosentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unidentified.
pentobarbital will reduce the level or result of fosphenytoin by impacting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Check.
pentobarbital will increase toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. CYP3A4 inducers may well increase the metabolism of ifosfamide to its Energetic alkylating metabolites.
Monoamine oxidase inhibitors (MAOI) may well inhibit barbiturate metabolism and lengthen barbiturate effects; observe intently
pentobarbital will minimize the extent or impact of ramelteon by affecting hepatic enzyme CYP2C9/10 metabolism. Minimal/Importance Not known.
pentobarbital will lower the level or result of sunitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Caution/Monitor. Drugs that enhance delta-aminolevulinic acid synthetase may perhaps reduce hemin impact.
Monitor Closely (1)pentobarbital will lessen the extent or impact of fentanyl intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Coadministration of fentanyl with CYP3A4 inducers could lead to your reduce in fentanyl plasma concentrations, deficiency of efficacy or, maybe, progress click here of the withdrawal syndrome within a affected individual who has formulated Actual physical dependence to fentanyl. Right after stopping a CYP3A4 inducer, since the effects of your inducer drop, the fentanyl plasma concentration will increase which could boost or lengthen both equally the therapeutic and adverse effects.
pentobarbital will lessen the extent or effect of ondansetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. No dosage adjustment for ondansetron is usually recommended for clients on these drugs.
With therapeutic doses of TCAs, barbiturates boost metabolism and reduce blood concentrations of TCAs.
pentobarbital will lessen the level or influence of voriconazole by impacting hepatic enzyme CYP2C9/ten metabolism. Minor/Importance Unknown.